Endotracheal adrenaline in cardiac arrest due to near-fatal asthma: a case study

05 May 2012
Volume 4 · Issue 5

Abstract

A case report of respiratory arrest in a patient with an out-of-hospital, near fatal asthma (NFA) attack; successfully resuscitated with treatment that included endotracheal adrenaline is described.

This report demonstrates that endotracheal epinephrine (adrenaline may have a role in the resuscitation of asphyxic asthma. Adrenaline is a recognised β2 agonist and its smooth muscle relaxation properties are known to reverse bronchospasm. Ventilating patients with severe bronchospasm resulting from asphyxic asthma is known to be difficult. This report shows that instilling adrenaline via the endotracheal tube to a patient in cardio-respiratory arrest, resulted in relief of bronchospasm, reduction in airways resistance and a subsequent improvement of the operator's ability to ventilate.

United Kingdom statistics for asthma show 1 204 deaths from asthma in 2008 (Asthma UK, 2008). Although death rates from asthma are declining, near-fatal asthma (NFA) still presents a signifcant challenge to emergency responders, with most asthma deaths occurring outside of the hospital (Rodrigo et al, 2004). Restrepo and Peters (2008) define near fatal asthma as ‘typically associated with the presence of hypercapnoea, acidaemia, altered state of consciousness and the development of cardio-respiratory arrest requiring endotracheal intubation and mechanical ventilation’.

NFA is a subtype of asthma with unique risk factors and variable presentation that requires early recognition and aggressive intervention. (Restrepo, 2008). United Kingdom ambulance dispatch records show that around 17 % of ambulance calls are prioritised as breathing diffculties (Clawson, 2008). Of these, around 30 % are identified as being asthmatic. While all of these calls cannot be attributed to NFA, it is reasonable to surmise that paramedics are called to patients with life-threatening asthma and some of these may later be categorised as near-fatal.

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