Does adrenaline improve long-term outcomes after out-of-hospital cardiac arrest?

Adrenaline has been an integral component of advanced life support from the birth of modern cardiopulmonary resuscitation (CPR) in the early 1960s.The findings from randomised trials and observational studies indicate that giving adrenaline in out-of-hospital cardiac arrest (OHCA) increases the rate of return of spontaneous circulation (ROSC) but that longer-term outcomes (survival to hospital discharge and neurologically favourable survival) are either worse or, at best, neutral.PARAMEDIC2: The Adrenaline Trial should answer once and for all the question of whether giving doses of adrenaline 1 mg during CPR improves long-term outcome from OHCA. As such, it is the most important cardiac arrest research study ever to be undertaken in the United Kingdom.

Subscribe to get full access to the Journal of Paramedic Practice

Thank you for vising the Journal of Paramedic Practice and reading our archive of expert clinical content. If you would like to read more from the only journal dedicated to those working in emergency care, you can start your subscription today for just £48.

CPD Focus

Reading the Journal of Paramedic Practice counts towards your professional development

Develop your career

We provide professional information dedicated to paramedics covering training, education and jobs

Stay informed

Get the latest clinical information to ensure you are aware of the latest think and best practice in paramedicne

Subscribe now

Already registered? - Sign in here

Keep up to date with Journal of Paramedic Practice!

Sign up to Journal of Paramedic Practice’s regular newsletters and keep up-to-date with the very latest clinical research and CPD we publish each month.