Does adrenaline improve long-term outcomes after out-of-hospital cardiac arrest?


Adrenaline has been an integral component of advanced life support from the birth of modern cardiopulmonary resuscitation (CPR) in the early 1960s.The findings from randomised trials and observational studies indicate that giving adrenaline in out-of-hospital cardiac arrest (OHCA) increases the rate of return of spontaneous circulation (ROSC) but that longer-term outcomes (survival to hospital discharge and neurologically favourable survival) are either worse or, at best, neutral.PARAMEDIC2: The Adrenaline Trial should answer once and for all the question of whether giving doses of adrenaline 1 mg during CPR improves long-term outcome from OHCA. As such, it is the most important cardiac arrest research study ever to be undertaken in the United Kingdom.

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