Pre-hospital paediatric seizures: midazolam versus diazepam

This literature review aims to scope the current evidence for use of diazepam and midazolam for managing seizures in children, with particular focus on pre-hospital management. Many emergency departments now use buccal midazolam as first-line treatment for managing paediatric seizures, while ambulance services continue to use diazepam via the rectal (PR) or intravenous (IV) route.This review concludes that the evidence for the continued use of diazepam by ambulance services should be reconsidered if we are to provide the best standard of care for our paediatric patients—and move our treatment in line with best practice, and what is considered the norm in a hospital setting.

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