Prognostic value of lactate in out-of-hospital cardiac arrest: a prospective cohort study
Karl Charlton, Hayley Stagg
Saturday, April 2, 2022
The prognostic role of lactate in out-of-hospital cardiac arrest (OHCA) remains unclear.
To explore serum lactate as a predictor of return of spontaneous circulation in patients experiencing OHCA after arrival at hospital.
This 13-month prospective observational cohort study involved patients aged ≥18 years. Serum lactate levels were measured during cardiopulmonary resuscitation before ROSC. Patients were divided into two groups by lactate level: Group 1, low (≤9.9 mmol/l) and Group 2, high (≥10 mmol/l).
105 patients were included, 50 in group 1 and 55 group 2. Median lactate were 7.4 mmol/l and 14.2 mmol/l respectively. More patients in group 1 were found with ventricular fibrillation (40% versus 14.5%; <em>P</em>≤0.01), obtained ROSC more quickly (37 minutes 38 seconds versus 39 minutes 13 seconds; <em>P</em>=0.79) and achieved short-term survival (survived >24 hours) (40% versus 23.5%; <em>P</em>=0.32), versus group 2; prediction of survival did not reach statistical significance.
Lower lactate levels in OHCA appear to be associated with better short-term outcomes but the cut-off points regarding survival remain unclear.
Subscribe to get full access to the Journal of Paramedic Practice
Thank you for vising the Journal of Paramedic Practice and reading our archive of expert clinical content. If you would like to read more from the only journal dedicated to those working in emergency care, you can start your subscription today for just £48.
Reading the Journal of Paramedic Practice counts towards your professional development
Develop your career
We provide professional information dedicated to paramedics covering training, education and jobs
Get the latest clinical information to ensure you are aware of the latest think and best practice in paramedicne
Already registered? - Sign in here