References

The TIMI risk score for unstable angina/non-ST elevation MI.. JAMA. 2000; 284:(7)835-42

Beneft of early invasive therapy in acute coronary syndromes: A meta-analysis of contemporary randomized clinical trials. J Am Coll Cardiol. 2006; 48:(7)1319-25

Outcomes in patients with acute non-Q-wave myocardial infarction randomly assigned to an invasive as compared with a conservative management strategy. N Engl J Med. 1998; 338:(25)1785-92

Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofban.. N Engl J Med. 2001; 344:(25)1879-87

How should patients with unstable angina and non-ST-segment elevation myocardial infarction be managed? A meta-analysis of randomised trials.. Am J Med. 2005; 118:(5)465-74

Management and 6-month outcomes in elderly and very elderly patients with high-risk non-ST-elevation acute coronary syndromes: The global registry of acute coronary events.. Eur Heart J. 2008; 29:(10)1275-82

Early invasive versus selectively invasive management for acute coronary syndromes.. N Engl J Med. 2005; 353:(11)1095-104

Clinical and arteriographic characterisation of patients with unstable anginawithout critical coronary arterial narrowing (from the TIMI-IIIA trial).. Am J Cardiol. 1994; 74:(6)531-7

Interventional versus conservative treatment for patients with unstable angina or non-ST-elevation myocardial infarction: the British Heart Foundation RITA 3 randomised trial.. Lancet. 2002; 360:(9335)743-51

Rationale and design of the GRACE (Global Registry of Acute Coronary Events) Project: a multinational registry of patients hospitalized with acute coronary syndromes.. Am Heart J. 2001; 141:(2)190-9

GRACE. Global Registry of Acute Coronary Events.. 2012. http//www.outcomes-umassmed.org/GRACE/default.aspx (accessed 26 July 2012)

ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation.. Eur Heart J. 2011; 32:(23)2999-3054

Early invasive versus conservative strategies for unstable angina and non-ST elevation myocardial infarction in the stent era.. Cochrane Database of Syst Rev. 2010; 19:(3)

Right bundle-branch block in acute coronary syndrome: diagnostic and therapeutic implications for the emergency physician.. Am J Emerg Med. 2009; 27:(9)1130-41

Health-related quality of life after interventional or conservative strategyin patients with unstable angina or non-ST-segment elevation myocardial infarction.. One-year results of the third randomized intervention trial of unstable angina (RITA-3) J Am Coll Cardiol. 2005; 42:(2)221-8

Incidence and clinical impact of right bundle branch block in patients with acute myocardial infarction: ST elevation myocardial infarction versus non-ST elevation myocardial infarction.. Am Heart J. 2008; 156:(2)256-61

5-year outcomes in the FRISC-II randomised trial of an invasive versus a non-invasive strategy in non-ST-elevation acute coronary syndrome: a follow-up study.. Lancet. 2006; 368:(9540)998-1004

Chest pain presenting to the emergency department–to stratify risk with GRACE or TIMI?. Resuscitation. 2007; 74:(1)90-3

Coronary heart disease in South Asians overseas: a review.. Journal of Clinical Epidemiology. 2004; 42:(7)597-609

Early versus delayed invasive intervention in acute coronary syndromes.. N Engl J Med. 2009; 360:(21)2165-75

Treatment of refractory unstable angina in geographically isolated areas without cardiac surgery.. Invasive versus conservative strategy (TRUCS study). Eur Heart J. 2000; 21:(23)1954-9

Myocardial Ischaemia National Audit Project (MINAP). How the NHS cares for patients with heart attack. Tenth Public Report 2011.. 2011. http//www.hqip.org.uk/assets/NCAPOP-Library/MINAP-public-report-2011.pdf (accessed 20 July 2012)

STEMI and NSTEMI: are they so different? 1 year outcomes in acute myocardial infarction as defined by the ESC/ACC definition (the OPERA registry).. Eur Heart J. 2007; 28:(12)1409-17

Evaluation of prolonged antithrombotic pretreatment (‘cooling-off’ strategy) before intervention in patients with unstable coronary syndromes.. JAMA. 2003; 290:(12)1593-9

NICE. Unstable angina and NSTEMI: the early management of unstable angina and non-ST-segment-elevation myocardial infarction.. 2010. http//www.nice.org.uk/nicemedia/live/12949/47921/47921.pdf (accessed 20 July 2012)

Prognostic implications of angiographically normal and insignificantly narrowed coronary arteries.. Am J Cardiol. 1986; 58:(13)1181-7

Prevalence, predictors, and outcomes of patients with non-ST-segment elevation myocardial infarction and insignificant coronary artery disease: results from the Can Rapid risk stratification of Unstable angina patients Suppress Adverse outcomes with Early implementation of the ACC/AHA Guidelines (CRUSADE) initiative.. Am Heart J. 2006; 152:(4)641-7

Presentation and late outcome of myocardial infarction in the absence of angiographically significant coronary artery disease.. Am J Cardiol. 1988; 62:(7)363-7

Cardiovascular risk in South Asians.. Postgrad Med J. 2008; 84:(996)518-23

Immediate versus deferred coronary angioplasty in non-ST-segment elevation acute coronary syndromes.. Heart. 2009; 95:(10)807-12

Clinical and therapeutic profile of patients presenting with acute coronary syndromes who do not have significant coronary artery disease.. Circulation. 2000; 102:(10)1101-06

Prognostic value of the admission electrocardiogram in acute coronary syndromes.. JAMA. 1999; 281:(8)707-13

Value of first day angiography/angioplasty in evolving non-ST segment elevation myocardial infarction: an open multicentre randomized trial.. European Heart Journal. 2002; 23:(3)230-38

Warning symptoms before major myocardial infarction.. Br Heart J. 1970; 32:(6)833-8

Delay to angiography and outcomes following presentation with high-risk, non-ST-elevation acute coronary syndromes: results from the Global Registry of Acute Coronary Events.. Heart. 2009; 95:(3)211-5

Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction.. Results of the TIMI IIIB trial. Thrombolysis in myocardial ischemia. Circulation. 1994; 89:(4)1545-56

Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study.. Lancet. 1999; 354:(9180)708-15

Prognostic differences between different types of bundle branch block during the early phase of acute myocardial infarction: insights from the Hirulog and early reperfusion or occlusion (HERO)-2 trial.. Eur Heart J. 2006; 27:(1)21-8

World Health Organization (WHO). The top 10 causes of death [Factsheet 310].. 2011. http//www.who.int/mediacentre/factsheets/fs310/en/index.html (accessed 20 July 2012)

2011 ACCF/ AHA focused update of the guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline): a report of the Americancollege of cardiology foundation/American heart association task force on practice guidelines developed in collaborationwith the American college of emergency physicians, society for cardiovascular angiography and interventions, and the society of thoracic surgeons.. J Am Coll Cardiol. 2011; 57:(19)1920-59

High-risk non-ST elevation acute coronary syndromes (NSTEACS) for paramedics

06 August 2012
Volume 4 · Issue 8

Abstract

Pre-hospital clinicians frequently encounter patients suffering acute coronary syndromes (ACS) and they form an integral part in recognising and conveying the ST-elevation myocardial infraction (STEMI) patient to the most appropriate destination, namely the heart attack centre (HAC). The emphasis has been upon the recognition and subsequent management of the STEMI patient. The non-ST elevation acute coronary syndrome (NSTEACS) patient has a similar mortality and morbidity yet does not receive the same pathways as STEMI. This article aims to provide an understanding based on a case study around NSTEACS with supporting evidence relating to risk stratification, clinical trials and clinical guidelines of what needs to be developed to enhance the care we provide to the NSTEAC patient in the pre-hospital arena.

Ischaemic heart disease (IHD) is the leading cause of death worldwide with 12.8% of all deaths attributed to this (World Health Organization (WHO), 2011). A number of IHD patients may also develop an acute coronary syndrome (ACS). Ambulance clinicians commonly encounter patients suffering ACS, this being unstable angina (UA), non-ST elevation myocardial infarction (NSTEMI) and ST elevation myocardial infarction (STEMI).

Differentiating between the three can be challenging, however with good history from the patient, including history of the complaint along with established cardiac risk factors, familial history and a good understanding of electrocardiograms (ECGs), differentiating between STEMI and Non ST elevation acute coronary syndromes (NSTEACS) can be clinically suspected and achieved with blood biomarker assays.However, all three types of ACS would warrant the same drug therapy from paramedics and currently only STEMI patients attend heart attack centres (HACs) as standard practice where the patients may undergo primary percutaneous coronary intervention (pPCI). These patients undergo an assessment by a cardiologist and angiography commonly followed by re-vascularisation and stent insertion if required to open up the affected coronary artery/s. NSTEACS patients could be seen to be pre-STEMI as their stenosis may be critical and may develop into a STEMI, therefore benefiting from early expert opinion to optimise future heart function and if required revascularisation.

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