References

Adams J, Hillier-Brown FC, Moore HJ Searching and synthesising ‘grey literature’ and ‘grey information’ in public health: critical reflections on three case studies. Syst Rev. 2016; 5:(1) https://doi.org/10.1186/s13643-016-0337-y

Almeida CPBD, Goulart BNGD. How to avoid bias in systematic reviews of observational studies. Revista CEFAC. 2017; 19:(4)551-555 https://doi.org/10.1590/1982-021620171941117

American Paramedic Association. Paramedic manifesto. 2019. https//americanparamedics.org/page/Manifesto (accessed 10 April 2022)

Attia A. Why should researchers report the confidence interval in modern research. Middle East Fertil Soc J. 2005; 10:(1)78-81

Backus BE, Six AJ, Kelder JC A prospective validation of the HEART score for chest pain patients at the emergency department. Int J Cardiol. 2013; 168:(3)2153-2158 https://doi.org/10.1016/j.ijcard.2013.01.255

Best P. Can paramedics avoid A&E departments with patients complaining of non-traumatic chest pain?. J Paramed Pract. 2017; 9:(4)165-170 https://doi.org/10.12968/jpar.2017.9.4.165

Beygui F, Castren M, Brunetti ND Pre-hospital management of patients with chest pain and/or dyspnoea of cardiac origin. A position paper of the Acute Cardiovascular Care Association (ACCA) of the ESC. Eur Heart J Acute Cardiovasc Care. 2020; 9:59-81 https://doi.org/10.1177/2048872615604119

Body R, Carlton E, Sperrin M Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid: single biomarker re-derivation and external validation in three cohorts. Emerg Med J. 2017; 34:(6)349-356 https://doi.org/10.1136/emermed-2016-205983

Body R, Almashali M, Morris N Diagnostic accuracy of the T-MACS decision aid with a contemporary point-of-care troponin assay. Heart. 2019; 105:(10)768-774 https://doi.org/10.1136/heartjnl-2018-313825

Brady W, de Souza K. The HEART score: a guide to its application in the emergency department. Turk J Emerg Med. 2018; 18:(2)47-51 https://doi.org/10.1016/j.tjem.2018.04.004

Carlton EW, Than M, Cullen L, Khattab A, Greaves K. ‘Chest pain typicality’ in suspected acute coronary syndromes and the impact of clinical experience. Am J Med. 2015; 128:(10)1109-1116.e2 https://doi.org/10.1016/j.amjmed.2015.04.012

Chapman AR, Stewart S, Mills NL. Contemporary point of care cardiac troponin testing in suspected acute coronary syndrome. Heart. 2019; 105:(10)740-741 https://doi.org/10.1136/heartjnl-2018-314306

Colbeck M. Paramedic diagnosis of acute coronary syndrome in the out-of-hospital patient with acute, non-traumatic chest pain. Australasian Journal of Paramedicine. 2016; 13:(4) https://doi.org/10.33151/ajp.13.4.523

Denktas AE, Anderson HV, McCarthy J, Smalling RW. Total ischemic time: the correct focus of attention for optimal ST-segment elevation myocardial infarction care. JACC Cardiovasc Interv. 2011; 4:(6)599-604 https://doi.org/10.1016/j.jcin.2011.02.012

Dettori JR. Loss to follow-up. Evid Based Spine Care J. 2011; 2:(1)7-10 https://doi.org/10.1055/s-0030-1267080

Ducas RA, Wassef AW, Jassal DS To transmit or not to transmit: how good are emergency medical personnel in detecting STEMI in patients with chest pain?. Can J Cardiol. 2012; 28:(4)432-437 https://doi.org/10.1016/j.cjca.2012.04.008

Fanaroff AC, Rymer JA, Goldstein SA, Simel DL, Newby LK. Does this patient with chest pain have acute coronary syndrome?. JAMA. 2015; 314:(18)1955-1965 https://doi.org/10.1001/jama.2015.12735

Frisoli TM, Nowak R, Evans KL Henry Ford HEART score randomized trial: rapid discharge of patients evaluated for possible myocardial infarction. Circ Cardiovasc Qual Outcomes. 2017; 10:(10) https://doi.org/10.1161/CIRCOUTCOMES.117.003617

Funder JL, Ross L, Ryan S. How effective are paramedics at interpreting ECGs in order to recognize STEMI? A systematic review. Australasian Journal of Paramedicine. 2020; https://doi.org/10.33151/ajp.17.772

Giannitsis E, Katus HA. Cardiac troponin level elevations not related to acute coronary syndromes. Nat Rev Cardiol. 2013; 10:(11)623-634 https://doi.org/10.1038/nrcardio.2013.129

Hale P, Lowe R, Seamon JP, Jenkins JJ. Paramedic electrocardiogram and rhythm identification: a convenient training device. Prehosp Disaster Med. 2011; 26:(5)342-345 https://doi.org/10.1017/S1049023X11006558

Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003; 327:(7414)557-560 https://doi.org/10.1136/bmj.327.7414.557

Higgins JPT, Thomas J, Chandler J Cochrane handbook for systematic reviews of interventions.: Cochrane Collaboration and John Wiley & Sons; 2019 https://doi.org/10.1002/9781119536604

Huang X, Lin J, Demner-Fushman D. Evaluation of PICO as a knowledge representation for clinical questions. AMIA Annu Symp Proc. 2006; 2006:359-363

Ibanez B, James S, Agewall S 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018; 39:(2)119-177 https://doi.org/10.1093/eurheartj/ehx393

Ioannidis JP, Salem D, Chew PW, Lau J. Accuracy and clinical effect of out-of-hospital electrocardiography in the diagnosis of acute cardiac ischemia: a meta-analysis. Ann Emerg Med. 2001; 37:(5)461-470 https://doi.org/10.1067/mem.2001.114904

Ishak M, Ali D, Fokkert MJ Fast assessment and management of chest pain patients without ST-elevation in the pre-hospital gateway (FamouS Triage): ruling out a myocardial infarction at home with the modified HEART score. Eur Heart J Acute Cardiovasc Care. 2018; 7:(2)102-110 https://doi.org/10.1177/2048872616687116

Jager J, Putnick DL, Bornstein MH. More than just convenient: the scientific merits of homogeneous convenience samples. Monogr Soc Res Child Dev. 2017; 82:(2)13-30 https://doi.org/10.1111/mono.12296

Jungbauer C, Hupf J, Giannitsis E Analytical and clinical validation of a point-of-care cardiac troponin t test with an improved detection limit. Clin Lab. 2017; 63:(4)633-645 https://doi.org/10.7754/Clin.Lab.2016.160814

Khalid U, Jneid H, Denktas AE. The relationship between total ischemic time and mortality in patients with STEMI: every second counts. Cardiovasc Diagn Ther. 2017; 7:S119-S124 https://doi.org/10.21037/cdt.2017.05.10

Chapter 5: collecting data. 2022. https//training.cochrane.org/handbook/current/chapter-05 (accessed 10 April 2022)

Mahler SA, Riley RF, Hiestand BC The HEART Pathway randomized trial: identifying emergency department patients with acute chest pain for early discharge. Circ Cardiovasc Qual Outcomes. 2015; 8:(2)195-203 https://doi.org/10.1161/CIRCOUTCOMES.114.001384

Mahler SA, Stopyra JP, Apple FS Use of the HEART Pathway with high sensitivity cardiac troponins: a secondary analysis. Clin Biochem. 2017; 50:(7–8)401-407 https://doi.org/10.1016/j.clinbiochem.2017.01.003

Avoiding bias in selecting studies. 2013. https//www.ncbi.nlm.nih.gov/books/NBK126701 (accessed 10 April 2022)

Melki D, Jernberg T. HEART score: a simple and useful tool that may lower the proportion of chest pain patients who are admitted. Crit Pathw Cardiol. 2013; 12:(3)127-131 https://doi.org/10.1097/HPC.0b013e3182953359

Mhaskar R, Emmanuel P, Mishra S, Patel S, Naik E, Kumar A. Critical appraisal skills are essential to informed decision-making. Indian J Sex Transm Dis AIDS. 2009; 30:(2)112-119 https://doi.org/10.4103/0253-7184.62770

Michel JB, Schussler JM. The trouble with troponin. Proc (Bayl Univ Med Cent). 2018; 31:(2)238-239 https://doi.org/10.1080/08998280.2018.1435121

Myocardial Ischaemia National Audit Project. 2020 summary report. MINAP. 2021. https//tinyurl.com/3svd7k5c (accessed 10 April 2022)

National Institute for Health and Care Excellence. Recommendations. 2010. https//www.nice.org.uk/guidance/cg95/chapter/Recommendations (accessed 10 April 2022)

National Institute for Health and Care Excellence. Recommendations. 2016. https//www.nice.org.uk/guidance/cg95/chapter/Recommendations (accessed 10 April 2022)

National Institute for Health and Care Excellence. Recommendations. 2020. https//www.nice.org.uk/guidance/ng185/chapter/Recommendations (accessed 10 April 2022)

Neumann JT, Sörensen NA, Schwemer T Diagnosis of myocardial infarction using a high-sensitivity troponin I 1-hour algorithm. JAMA Cardiol. 2016; 1:(4)397-404 https://doi.org/10.1001/jamacardio.2016.0695

Niven WGP, Wilson D, Goodacre S, Robertson A, Green SJ, Harris T. Do all HEART scores beat the same: evaluating the interoperator reliability of the HEART score. Emerg Med J. 2018; 35:(12)732-738 https://doi.org/10.1136/emermed-2018-207540

Nunan D, Aronson J, Bankhead C. Catalogue of bias: attrition bias. BMJ Evid Based Med. 2018; 23:(1)21-22 https://doi.org/10.1136/ebmed-2017-110883

Panovska-Griffiths J, Ross J, Elkhodair S, Baxter-Derrington C, Laing C, Raine R. Exploring overcrowding trends in an inner city emergence department in the UK before and during COVID-19 epidemic. BMC Emerg Med. 2021; 21:(1) https://doi.org/10.1186/s12873-021-00438-y

Park KC, Gaze DC, Collinson PO, Marber MS. Cardiac troponins: from myocardial infarction to chronic disease. Cardiovas Res. 2017; 113:(14)1708-1718 https://doi.org/10.1093/cvr/cvx183

Patnaik S, Shah M, Alhamshari Y Clinical utility of the HEART score in patients admitted with chest pain to an inner-city hospital in the USA. Coron Artery Dis. 2017; 28:(4)336-341 https://doi.org/10.1097/MCA.0000000000000474

Pedersen CK, Stengaard C, Friesgaard K Chest pain in the ambulance; prevalence, causes and outcome—a retrospective cohort study. Scand J Trauma Resusc Emerg Med. 2019; 27:(1) https://doi.org/10.1186/s13049-019-0659-6

Pilkington K, Boshnakova A, Clarke M, Richardson J. ‘No language restrictions’ in database searches: what does this really mean?. J Altern Complement Med. 2005; 11:(1)205-207 https://doi.org/10.1089/acm.2005.11.205

Pines JM, Pollack CV, Diercks DB, Chang AM, Shofer FS, Hollander JE. The association between emergency department crowding and adverse cardiovascular outcomes in patients with chest pain. Acad Emerg Med. 2009; 16:(7)617-625 https://doi.org/10.1111/j.1553-2712.2009.00456.x

Poldervaart JM, Langedijk M, Backus BE Comparison of the GRACE, HEART and TIMI score to predict major adverse cardiac events in chest pain patients at the emergency department. Int J Cardiol. 2017; 227:656-661 https://doi.org/10.1016/j.ijcard.2016.10.080

Reaney PD, Elliott H, Cooper J. A comparison of the HEART, TIMI and GRACE scores in the prediction of a major adverse cardiac event (MACE) in patients presenting with Undifferentiated cardiac chest pain: a prospective cohort study in a UK population. Emerg Med J. 2016; 33:(12)916-917 https://doi.org/10.1136/emermed-2016-206402.34

Scottish Intercollegiate Guidelines Network. Checklists. 2020. https//www.sign.ac.uk/what-we-do/methodology/checklists/ (accessed 10 April 2022)

Sedgwick P. Retrospective cohort studies: advantages and disadvantages. BMJ. 2014; 348:g1072-g1072 https://doi.org/10.1136/bmj.g1072

Six AJ, Backus BE, Kelder JC. Chest pain in the emergency room: value of the HEART score. Neth Heart J. 2008; 16:(6)191-196 https://doi.org/10.1007/BF03086144

Six AJ, Cullen L, Backus BE The HEART score for the assessment of patients with chest pain in the emergency department: a multinational validation study. Crit Pathw Cardiol. 2013; 12:(3)121-126 https://doi.org/10.1097/HPC.0b013e31828b327e

Stopyra JP, Harper WS, Higgins TJ Prehospital modified HEART score predictive of 30-day adverse cardiac events. Prehosp Disaster Med. 2018; 33:(1)58-62 https://doi.org/10.1017/S1049023X17007154

Stopyra JP, Snavely AC, Smith LM Pre-hospital use of a modified HEART Pathway and point-of-care troponin to predict cardiovascular events. PLoS One. 2020; 15:(10) https://doi.org/10.1371/journal.pone.0239460

Suzuki K, Komukai K, Nakata K The usefulness and limitations of point-of-care cardiac troponin measurement in the emergency department. Intern Med. 2018; 57:(12)1673-1680 https://doi.org/10.2169/internalmedicine.0098-17

Torralba F, Navarro A, la Hoz JC HEART, TIMI, and GRACE scores for prediction of 30-day major adverse cardiovascular events in the era of high-sensitivity troponin. Arq Bras Cardiol. 2020; 114:(5)795-802 https://doi.org/10.36660/abc.20190206

Trivedi K, Schuur JD, Cone DC. Can paramedics read ST-segment elevation myocardial infarction on prehospital 12-lead electrocardiograms?. Prehosp Emerg Care. 2009; 13:(2)207-214 https://doi.org/10.1080/10903120802706153

Ambulance Response Programme: evaluation of phase 1 and phase 2. Final report. 2017. https//www.england.nhs.uk/publication/arp-evaluation/ (accesssed 10 April 2022)

Van Den Berg P, Body R. The HEART score for early rule out of acute coronary syndromes in the emergency department: a systematic review and meta-analysis. Eur Heart J Acute Cardiovasc Care. 2018; 7:(2)111-119 https://doi.org/10.1177/2048872617710788

van Dongen DN, Tolsma RT, Fokkert MJ Pre-hospital risk assessment in suspected non-ST-elevation acute coronary syndrome: a prospective observational study. Eur Heart J Acute Cardiovasc Care. 2020a; 9:5-12 https://doi.org/10.1177/2048872618813846

van Dongen DN, Tolsma RT, Fokkert MJ Referral decisions based on a prehospital HEART score in suspected non-ST-elevation acute coronary syndrome: design of the FamouS Triage 3 study. Future Cardiol. 2020b; 16:(4)217-226 https://doi.org/10.2217/fca-2019-0030

van Dongen DN, Badings EA, Fokkert MJ Pre-hospital versus hospital acquired HEART score for risk classification of suspected non ST-elevation acute coronary syndrome. Eur J Cardiovasc Nurs. 2021; 20:(1)40-47 https://doi.org/10.1177/1474515120927867

van Meerten KF, Haan RMA, Dekker IMC, van Zweden HJJ, van Zwet EW, Backus BE. The interobserver agreement of the HEART-score, a multicentre prospective study. Eur J Emerg Med. 2021; 28:(2)111-118 https://doi.org/10.1097/MEJ.0000000000000758

Wibring K, Herlitz J, Christensson L, Lingman M, Bång A. Prehospital factors associated with an acute life-threatening condition in non-traumatic chest pain patients—a systematic review. Int J Cardiol. 2016; 219:373-379 https://doi.org/10.1016/j.ijcard.2016.06.066

EMS in The Netherlands: a Dutch treat?. 2005. https//www.jems.com/patient-care/ems-netherlands-dutch-treat/ (accessed 10 April 2022)

The efficacy of the HEART score in prehospital settings

02 May 2022
Volume 14 · Issue 5

Abstract

Background:

HEART scores are a well-validated tool used to risk stratify patients with chest pain in the emergency department. Currently, no triage or risk stratification tool is available in the UK prehospital arena.

Methods:

A comprehensive literature search was carried out to determine the effectiveness of HEART score use by paramedics in the prehospital environment.

Findings:

Prehospital HEART scores completed by paramedics appear to have a high sensitivity and negative predictive value for detecting major adverse cardiac events. The use of high-sensitivity cardiac troponin assays or a prehospital modified HEART Pathway may allow patients to be triaged based on a single point-of-care (POC) cardiac troponin test. As POC devices improve, this is likely to increase the accuracy of paramedic HEART scores. Additionally, there are some differences between HEART scores calculated by doctors and paramedics.

Conclusion:

The use of HEART scores prehospitally has the potential to improve patient outcomes. However, issues remain over the accuracy of POC devices and with paramedic interpretation of electrocardiograms and cardiac history-taking. Furthermore, the lack of POC testing in current UK paramedic scopes of practice raises questions over the practicality of introducing HEART scores, which would rely on POC testing.

Chest pain is one of the most common presentations to emergency departments (EDs) and ambulance services alike, accounting for approximately 10% of UK ambulance responses (Best, 2017; Turner et al, 2017; Pedersen et al, 2019).

Being able to identify the aetiology of chest pain is a core component of paramedic practice as it has many life-threatening causes, including ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI), aortic dissection, pericarditis and oesophageal perforation.

European Society of Cardiology guidelines and UK research highlight that NSTEMI has a greater prevalence than STEMI (in a ratio of approximately 2:1) as a cause of acute chest pain (Ibanez et al, 2018; Myocardial Ischaemia National Audit Project (MINAP), 2021).

Notwithstanding other clinical reasons (such as inadequate analgesia), the lack of biochemical tests in a prehospital environment means many patients with chest pain (without STEMI) are transported to the ED only to be discharged after a blood test. This is caused by a lack of prehospital capability to use and measure cardiac biomarkers as part of the decision-making process in this population (Wibring et al, 2016; Pedersen et al, 2019).

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