Comparison of buccal midazolam and rectal diazepam for seizures in children


Background: buccal midazolam and rectal diazepam are used as first-line drugs to control seizures in children. Immediate treatment and management of a continuing seizure is vital to ensure its safe, effective and prompt termination. Aim: To allow practitioners to evaluate the safety and efficacy of buccal midazolam versus rectal diazepam when treating seizures in children. Methods: A systematic review process was used to identify sources from CINAHL, MEDLINE, Embase, Google Scholar and the Cochrane Library, published in English between February 1999 and June 2010 Findings: five studies, totalling 676 patients, received buccal midazolam or rectal diazepam for seizures were identified. Treatment response occurred within 293 (76%) of 386 episodes treated with buccal midazolam and 248 (65%) of 383 episodes where rectal diazepam was used. There was no significant difference between groups regarding incidence of respiratory depression. Conclusion: the reviewed articles suggest that buccal midazolam is as effective as rectal diazepam for the termination of seizures.

Subscribe to get full access to the Journal of Paramedic Practice

Thank you for vising the Journal of Paramedic Practice and reading our archive of expert clinical content. If you would like to read more from the only journal dedicated to those working in emergency care, you can start your subscription today for just £48.

CPD Focus

Reading the Journal of Paramedic Practice counts towards your professional development

Develop your career

We provide professional information dedicated to paramedics covering training, education and jobs

Stay informed

Get the latest clinical information to ensure you are aware of the latest think and best practice in paramedicne

Subscribe now

Already registered? - Sign in here

Keep up to date with Journal of Paramedic Practice!

Sign up to Journal of Paramedic Practice’s regular newsletters and keep up-to-date with the very latest clinical research and CPD we publish each month.