Comparison of buccal midazolam and rectal diazepam for seizures in children
Katrina McKie, Peter Raby
Thursday, March 2, 2023
buccal midazolam and rectal diazepam are used as first-line drugs to control seizures in children. Immediate treatment and management of a continuing seizure is vital to ensure its safe, effective and prompt termination.
To allow practitioners to evaluate the safety and efficacy of buccal midazolam versus rectal diazepam when treating seizures in children.
A systematic review process was used to identify sources from CINAHL, MEDLINE, Embase, Google Scholar and the Cochrane Library, published in English between February 1999 and June 2010
five studies, totalling 676 patients, received buccal midazolam or rectal diazepam for seizures were identified. Treatment response occurred within 293 (76%) of 386 episodes treated with buccal midazolam and 248 (65%) of 383 episodes where rectal diazepam was used. There was no significant difference between groups regarding incidence of respiratory depression.
the reviewed articles suggest that buccal midazolam is as effective as rectal diazepam for the termination of seizures.
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