References

Age UK. Later life in the United Kingdom. 2019. https://tinyurl.com/5n6cvh6t (accessed 18 October 2023)

Association of Ambulance Chief Executives. Joint Royal Colleges Ambulance Liaison Committee (JRCALC) clinical guidelines 2019. 2020. https://tinyurl.com/23hv4jk4 (accessed 18 October)

Bowers B, Ryan R, Kuhn I, Barclay S. Anticipatory prescribing of injectable medications for adults at the end of life in the community: a systematic literature review and narrative synthesis. Palliat Med. 2019; 33:(2)160-177 https://doi.org/10.1177/0269216318815796

Department of Health and Social Care. End of life care strategy: promoting high quality care for all adults at the end of life. 2008. https://tinyurl.com/2he4hwxu (accessed 18 October 2023)

England E. Paramedics and medicines: legal considerations. J Paramed Pract. 2016; 8:(8)408-415 https://doi.org/10.12968/jpar.2016.8.8.408

Hoare S, Morris ZS, Kelly MP, Kuhn I, Barclay S. Do patients want to die at home? A systematic review of the UK literature, focused on missing preferences for place of death. PLoS One. 2015; 10:(11) https://doi.org/10.1371/journal.pone.0142723

Research briefing. Health performance indicators. 2016. https://tinyurl.com/nmax9fey (accessed 18 October)

Johnstone L. Facilitating anticipatory prescribing in end-of-life care. Pharm J. 2017; 298:(7901) https://doi.org/10.1211/PJ.2017.20202703

Kemp L, Holland R, Barclay S, Swift L. Pre-emptive prescribing for palliative care patients in primary care. BMJ Support Palliat Care. 2012; 2:A2.1-A2 https://doi.org/10.1136/bmjspcare-2012-000196.4

Maringe C, Spicer J, Morris M The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study. Lancet Oncol. 2020; 21:(8)1023-1034 https://doi.org/10.1016/S1470-2045(20)30388-0

NHS Wales. Just in case scheme. 2018. https://tinyurl.com/bdeyxsmy (accessed 18 October)

Pease NJ, Sundararaj JJ, O'Brian E, Hayes J, Presswood E, Buxton S. Paramedics and serious illness: communication training. BMJ Support Palliat Care. 2022; 12:(e2)e248-e255 https://doi.org/10.1136/bmjspcare-2018-001734

Royal Pharmaceutical Society. Professional guidance on the administration of medicines in healthcare settings. 2019. https://tinyurl.com/3mzbdpat (accessed 18 October)

Twycross R, Wilcock A. Palliative care formulary.Nottingham: Palliativedrugs.com; 2011

Impact of paramedics carrying just-in-case end-of-life care medication

02 November 2023
Volume 15 · Issue 11

Abstract

Background:

Early in the COVID-19 pandemic, it was predicted that frail community patients with symptoms of severe COVID-19 infection may need urgent symptom management—and that unless they had already been identified as being in their last weeks of life, they would be unlikely to have just-in-case (JIC) medications at home. The Welsh Ambulance Services NHS Trust therefore placed JIC medications on emergency ambulances to increase symptom management options for paramedics treating patients with symptoms of severe COVID-19 infection and/or associated with advanced end-stage illness.

Methods:

A review of medications to palliate symptoms of severe COVID-19 infection and advanced and terminal illness was undertaken. A verbal order process was implemented, allowing prescription-only medications to be administered by paramedics. Guidance, training and data capture processes were designed and implemented.

Results:

Symptoms associated with advanced cancer were the main reason for giving ambulance-based JIC medications, and midazolam and morphine were the most administered medicines. No adverse incidents were reported or recorded.

Conclusion:

Ambulance-based JIC medications were and continue to be appropriately administered, irrespective of life-limiting illness diagnosis. Although carrying JIC medicines on ambulances was introduced in response to the COVID-19 pandemic, 12 months of data collection indicates this is a safe, cost-effective, patient-centred practice.

With an ageing population and consequent rise in adult mortality, the need for health and social care services to provide high quality, integrated end-of-life care (EoLC) is ever increasing (Age UK, 2019).

While 70% of people at the end of life (EoL) were reported to prefer to die at home given the right support (Department of Health and Social Care, 2008), the individual patient's decision-making with respect to their preferred place of death is complex and often changes during their disease trajectory (Hoare et al, 2015). Given these complexities, it is important that all health professionals involved in caring for patients at the EoL have the necessary skills to facilitate patients achieving their preferred place of death. Appropriate management of pain, anxiety and other symptoms should therefore be a crucial goal, shared by patients, their family and carers as well as health professionals (Bowers et al, 2019).

When a pharmacological approach is needed to manage one or more of the common symptoms at EoL, such as pain, anxiety, breathlessness or nausea, this can be facilitated using anticipatory prescribing, where patients are provided with injectable medicines in their home for when and if they are needed (Twycross and Wilcock, 2011). These just-in-case (JIC) medicines are prescribed preventively and stored in the patient's home for administration by a health professional such as a nurse, doctor or paramedic.

Within Wales, paramedics have been able to administer JIC medications where appropriate and following shared decision-making with a senior clinician since 2016 (Association of Ambulance Chief Executives (AACE), 2019). During the process of shared decision-making, the paramedic will contact the patient's GP, an out-of-hours GP or a palliative medicine doctor to discuss the clinical situation, seeking the doctor's opinion on whether administration of JIC medication is appropriate and, if so, at what dose (AACE, 2019).

Unfortunately, for many EoL patients for whom pharmacological symptom management is needed, JIC medications will not have been pre-emptively prescribed, so will not be available in their home. A study of 12 GP practices in England reported that anticipatory prescribing or JIC medications were available in only 16% of their predictable deaths in the community (Kemp et al, 2012).

This situation was exacerbated during the COVID-19 pandemic when patients without current EoL symptoms, who had high levels of frailty or comorbidity and for whom hospital admission was not considered appropriate or indeed possible, presented to the ambulance service with symptoms of severe COVID-19 infection.

These patients would require palliation within the community, especially at the outset of the pandemic, when the COVID-19 demand on NHS intensive care units was predicted to exceed capacity, and some people in the community became severely unwell due to COVID-19 or other illnesses while self-isolating (Association of Palliative Medicine (APM), 2020). Therefore, JIC medications were introduced in Welsh ambulances in May 2020 to respond to this urgent need in the community and allow paramedics to better manage symptoms commonly seen in patients at the EoL, whether because of severe COVID-19 infection or advanced terminal illness. The addition of ambulance JIC medicines was hoped to reduce delays in symptom management and increase the likelihood of patients remaining in their preferred place of care, preventing the need for hospital admission.

This paper discusses the process of introducing JIC medication on ambulances in Wales and its impact on patient care and costs during the first 12 months of operation.

Methods

A review of parenteral medicines commonly prescribed at the end of life (Johnstone, 2017) was undertaken. This identified the appropriate JIC medications to manage the symptoms of severe COVID-19 infection and/or symptoms associated with advanced end-stage illnesses. This was done using integration of both the APM (2020) COVID-19 symptom control guidance and the established all-Wales JIC bag policy (NHS Wales, 2018).

Medicines

The review identified five parenteral EoLC medicines: morphine sulphate; midazolam; haloperidol; levomepromazine; and hyoscine hydrobromide. Morphine sulphate, the recommended medication for palliation of pain and end-stage breathlessness, was already carried on all ambulances in Wales.

The APM (2020) COVID-19 symptom control guidance states: ‘Patients can rapidly deteriorate with acute respiratory distress syndrome; this can be extremely distressing for the patient and family.’ The APM guide indicated that some patients were experiencing moderate to severe breathlessness, combined with moderate to severe agitation. In such cases, the APM guidance recommended the administration of midazolam and morphine, which is more effective than morphine alone.

The APM (2020) advises that ‘delirium may be a direct symptom of COVID-19, therefore treatment options may be limited’. It recommends that haloperidol is generally the drug of choice for the pharmacological management of moderate to severe delirium.

In addition, for patients in their final days or hours, levomepromazine was highlighted as being useful, and occasionally levomepromazine combined with midazolam was necessary for palliative severe agitation (APM, 2020).

Regarding medication for respiratory secretions, hyoscine hydrobromide was already standard within the all-Wales JIC bag policy (NHS Wales, 2018) and included in established Welsh Ambulance Services NHS Trust (WAST) EoL care training.

Verbal order process

Having identified which JIC medicines to procure and stock on ambulances, it was necessary to ensure these prescription-only medicines could be legally prescribed and administered. For speed of introduction, a robust verbal order process was developed. Although a patient group directive is the standard legal framework to allow registered health professionals who are not prescribers to administer a medicine to a predefined group of patients, their development and introduction can take several months. A verbal order would allow a paramedic to legally administer a non-prescribed, prescription-only medication that does not come under schedule 17 exemptions of the Medicines Act 2012 (England, 2016).

Medicines that are carried and licensed for administration by UK paramedics come under schedule 17 of the exemptions of the Human Medicines Act 2012—they are specific medicines that can be administered to sick or injured people who require immediate treatment without the need for a prescription. These medicines are also ratified by the JRCALC and listed within the JRCALC guidelines (AACE, 2019). Paramedics often refer to guidelines before administering a medication and JRCALC guidelines are online, easily accessible via smartphone or tablet.

Morphine has a Schedule 17 exemption in the Medicines Act 2012 and is within the JRCALC list (AACE, 2019). All other JIC medicines introduced were neither exempt under Schedule 17 nor included in the JRCALC guidelines.

As no other UK ambulance service had parenteral JIC medications on frontline ambulances, there was no evidence-based model of care to follow or established practice regarding the administration of these medicines within UK law.

With respect to the legal requirement of prescribing JIC medicines, the verbal order process under regulation 214 of the Human Medicines Regulations 2012 (Box 1) was identified as a method for doctors to supply a verbal order prescription by telephone to the paramedic on scene.

Verbal order process in the Human Medicines Regulations 2012

The verbal order process of regulation 214(b) of the Human Medicines Regulations 2012 states:

A person may not parenterally administer (otherwise than to himself or herself) a prescription only medicine unless the person is

  • an appropriate practitioner other than a European Economic Area (EEA) health professional; or
  • acting in accordance with the directions of such an appropriate practitioner. (Human Medicines Regulations, 2012)
  • The wording in Box 1 can be reframed as ‘When acting in accordance with a doctor—an appropriate practitioner is defined in regulation 213(3) as a doctor—a person may parentally administer a prescription-only medicine’. In other words, a paramedic may parenterally administer a prescription-only medicine when acting in accordance with the directions of a doctor.

    With respect specifically to the administration of the controlled drugs morphine and midazolam, controlled drugs are regulated under the Misuse of Drugs Act 1971 and the Misuse of Drugs Regulations 2001.

    The Misuse of Drugs Regulations 2001 regulation 7 states:

  • Any person may administer to another any drug specified in Schedule 5.
  • A doctor or dentist may administer to a patient any drug specified in Schedule 2, 3 or 4.
  • Any person other than a doctor or dentist may administer to a patient, in accordance with the directions of a doctor or dentist, any drug specified in Schedule 2, 3 or 4.
  • As mentioned above, a paramedic does not need a prescription or the involvement of a prescriber to administer parenteral morphine. Morphine administration lies within the exemptions in part 3, Schedule 17 of the Human Medicines Regulations 2012 (England, 2016). A registered paramedic may administer all medicines that are listed in schedule 17 for the immediate, necessary treatment of sick or injured people (England, 2016).

    In summary, a paramedic does not require a verbal order to administer morphine, but verbal orders were required for administration of all other ambulance JIC medicines.

    Professional administration guidance issued by the Royal Pharmaceutical Society (2019) states that verbal orders must be used only in exceptional circumstances and when no prescriber can be accessed without resulting in a delay in administering. The COVID-19 pandemic was exceptional and delayed administration of symptom-control medicines would have been detrimental to patient care.

    Although there is additional work for the supporting community doctor in terms of providing a verbal order, such professional shared decision-making between the paramedic and a doctor supports the paramedic in determining diagnosis, management plan and drug and dose to be administered (Pease et al, 2022).

    Guidance for staff

    Before the pilot went live, a standard operating procedure for JIC medicine administration was developed. Documents were also developed for symptom control and verbal order guidance and agreed with primary care and palliative care services across Wales.

    Drug monographs detailing indications for use, duration of action and possible side effects for each of the ambulance JIC medicines were written and made available on ambulances.

    In addition, the established WAST EoLC education modules were updated to include ambulance JIC medicine use. This EoLC education was made mandatory for all WAST paramedics.

    Data capture

    To ensure robust data capture of ambulance JIC medication use, drug codes specific to each new JIC medicine were introduced. Both drug code and dose were recorded on the patient clinical record (PCR) by the paramedic; this ensured accurate data capture of all uses of both ambulance and patients' own JIC medication.

    This data recorded onto the PCR could then be retrieved by the WAST clinical audit team. The clinical audit team were already validating every PCR before uploading them onto the electronic storage database. At the time of validation, any PCR with a JIC drug code entered onto it would be added to an additional spreadsheet that had been set up. All PCRs added to this spreadsheet were then reviewed by the trust EoLC lead.

    The review sought to capture the following data:

  • That professional shared decision-making was undertaken and, where applicable, a verbal order obtained. This was done by reading the clinical narrative, in which the paramedic would document the details of the doctor they had spoken with
  • The JIC drug that was administered: this was recorded with both a drug code and with the medication details being written down, including the dose and time of administration
  • The symptom that required a JIC medicine: this was done by reading the clinical narrative, in which the paramedic would document the details of the symptom
  • The underlying disease state of the person requiring a JIC medicine: this was done by reading the clinical narrative, in which the paramedic would document the patient's medical history.
  • Whether patients' own or WAST JIC medicines were administered: this was done by reading the clinical narrative, in which the paramedic would document the details of the medication and whether it was a verbal order (WAST JIC medicines, excluding morphine) or shared decision-making (patient's own medicines were already prescribed so no verbal order was required)
  • What happened after the paramedic left, i.e. who did they hand care over to and how long after paramedic attendance did the patient die? This was done by reading the clinical narrative, in which the paramedic would document the details of the person or organisation care was referred to. The date of death was accessed via the Welsh Demographic Service, an online clinical portal that includes patient date of death
  • Was there a second 999 call for the patient after initial paramedic attendance that required JIC medication administration? This was checked via an address search of the WAST call recording system.
  • Capturing adverse events

    Datix is the electronic data capture form used across the NHS. Datix is used to record any adverse incident or near miss.

    The line manager of a person recording an incident automatically receives the Datix information, but the reporter may also select other staff members or departments to ensure they are also made aware of the incident. In the case of any JIC medication errors, in addition to the reporter's line manager, the reporter could add the EoLC lead. If the reporter chose not to add the EoLC lead, the reporter's line manager would forward on the Datix to the EoLC lead for comment or investigation.

    Cost analysis

    As a means of assessing the impact of the project, a cost analysis would need to be undertaken. The cost analysis would include both initial set-up costs (Table 1) and subsequent ongoing respond and review costs (Table 2).


    Set-up costs
    Development of guidelines to include: Duration for document creation/adaptation: 5 hoursInput: consultant pharmacist (£33.73/hr)2x palliative care consultant (£70.88/hr)End-of-life care lead (£25.90/hr)Total: £1 006.95This equates to £12.75 per patient treated. This figure will reduce as the number of patients treated increases Standard operating procedure
    Symptom control guidance
    Verbal order guidance
    Verbal order prescriber form
    Drug monographs for:
  • Midazolam
  • Haloperidol
  • Levomepromazine
  • Hyoscine hydrobromide
  • Morphine
  • Implementation
    Procured medications:
  • Midazolam 10 mg/2 ml
  • Haloperidol 5 mg/ml
  • Levomepromazine 25 mg/ml
  • Hyoscine hydrobromide 400 mcg/ml
  • Morphine 10 mg/ml
  • £5.30/box of 5 amps (£1.06/vial)£18.25/box of 5 amps (£3.65/vial)£7.54/box of 5 amps (£1.5/vial)£8.50/box of 5 amps (£1.70/vial)£1.26 box of 10 amps (13p/vial)Free (donated)£40.85£12 255.00
    JIC medicine boxes
    Total cost per ambulance JIC box
    Total cost of 300 stocked JIC boxes
    Education
    Development of educational material:
  • Education videos on JIC medicines
  • Duration: 3 hoursInput: palliative care consultant (£70.88/hr)Total: £212.64This equates to £4.34 per patient treated. This figure will reduce as the number of patients treated increases
    Cost to upload onto established WAST digital platform £900 (including VAT)This equates to £18.37 per patient treated. This figure will reduce as the number of patients treated increases
    Continuing professional development hours (completed by paramedics and emergency medical technicians) Duration: 6 hoursParamedic (top of band £20.01)Emergency medical technicians (top of band £16.17)This equates to £217.99 per patient treated. This figure will reduce as the number of patients treated increases

    JIC: just in case; WAST: Welsh Ambulance Services NHS Trust


    999 emergency vehicle response
    Emergency ambulance with 2x paramedics (regardless of whether patient stays at home or is admitted to ED £272.42*
    Average on-scene time for ambulance at patient's place of care and associated cost Mean: 2 hrs 25 mins (range 48 mins–5 hrs 51 mins)Median: 2 hrs 15 minsInput: 2x paramedic (top of band £20.01)Total: £86.04
    Palliative care consultant time while providing on-scene advice Duration: 15 minsInput: palliative care consultant (£70.88/hr)Total: £17.72
    Hospital: assuming a patient is transferred from ED after 4 hours to a ward, and is likely to stay in hospital for at least a further 48 hours at a cost of £755.22**
    ED attendance:
  • Nurse care and housekeeper/environment
  • Doctor assessment at FP2 rate
  • ED triage
  • First hour cost made up of the above plus blood tests
  • Each subsequent hour in ED
  • ED discharge
  • £495.22
    One-day hospital stay £130.00††
    Transfer of patient back home following hospital stay. £56.42
    * £205.86 for see and treat; £292.09 for see, treat and convey (National NHS reference costs).

    ED: emergency department; JIC: just in case

    Broadly speaking, three set-up elements were necessary before rolling out the project: first, identification and procurement of necessary medication; second, establishment and documentation of procedures and guidelines including the verbal order process; and, finally, education, which involved a series of specifically developed educational videos uploaded to an existing digital platform.

    To enable a cost analysis, several assumptions were necessary. Details of the assumptions made will allow readers to interpret the cost analysis and extrapolate to their working environment.

    Results

    A 12-month review (July 2020–June 2021) of ambulance PCRs documenting all episodes of ambulance JIC medication administration identified:

  • Ambulance JIC medications were administered to 79 patients across Wales; some patients would have had more than one medicine or a repeat dose if required. Thirty-one (39%) were men. The median age was 69 years, and the age range was 37–100 years
  • Fifty-three (67%) patients died within 48 hours of accessing 999 and therefore administration of ambulance JIC medicine. All 53 died at home or in a care home; 44% of all patients were in a residential care home setting
  • Twenty-five (32%) of the 79 patients were in their last weeks of life when they accessed 999
  • The remaining patient accessed 999 because of severe COVID-19 symptoms. This patient was administered morphine and midazolam for agitation and severe breathlessness. The PCR documented good therapeutic effect and referral to community services. On follow-up at 3 months, the patient had recovered from COVID-19
  • Unsurprisingly, 68% of ambulance JIC medication administration was between 17:00 and 9:00 i.e. in the out-of-hours period
  • Four patients re-presented (second 999 call) on the same day following administration of ambulance JIC medication. Of the four, two required further symptom control before another provider was able to deliver care, and two calls were made following the death of the patient.
  • Although the primary driver for ambulance JIC medication introduction was the COVID-19 pandemic, from the project outset it was anticipated that data collection (including patient illness, symptoms managed and any adverse outcomes) could provide the evidence required regarding continuation of ambulance JIC medication after the pandemic.

    No adverse events were identified from either Datix or PCR review.

    Patients with symptoms associated with advanced cancer were the primary category for whom ambulance JIC medications were administered, accounting for 39% of cases, and given for distressing symptoms in COVID-19 patients, who comprised 11% of cases (Figure 1).

    Figure 1. Underlying disease state of patient requiring symptom management with ambulance just-in-case medications

    As mentioned above, patients may have their own parenteral JIC medications prescribed in anticipation of deterioration and for administration by a health professional such as a district nurse or paramedic. Where a patient's own JIC medicines were available, these were always administered in preference to ambulance JIC medication. Drug code data capture allowed comparison of symptoms managed using paramedic administration of ambulance JIC medication versus the patient's own JIC medicine (Figure 2).

    Figure 2. Symptoms managed with patients' own and ambulance just-in-case (JIC) medications

    Although breathlessness was the most common symptom requiring administration of JIC medicine, paramedics palliated the main five EoLC symptoms.

    No adverse events or Datix events were recorded, indicating that paramedics are safe and confident in administering both patients' own JIC medicines and ambulance JIC medication.

    The data suggest that there is insufficient anticipatory prescribing across all symptoms, with frequent reliance on ambulance JIC medicines.

    Figure 3. Number of times medications were administered from ambulance just-in-case (JIC) medications and patients' own JIC medications

    Cost analysis

    In 2020, using data on file, the WAST finance department calculated that a 999 emergency ambulance response cost £272.42, irrespective of whether the patient remained at home or was transferred to an emergency department (ED). This also includes the cost of administering ambulance JIC medications.

    If the patient was conveyed by emergency ambulance to the ED, the national target, where clinically appropriate, is to discharge the patient from the ED within 4 hours (James, 2016). For patients who have presented because of sudden deterioration and require symptom management, anecdotal evidence across Wales suggests these patients are admitted into the hospital from the ED, with the majority remaining in hospital for 48 hours. The assumption of 48 hours includes the time during the ED admission, subsequent transfer of the patient to a medical assessment ward followed by the planning and facilitation of patient discharge. This will incur a minimum cost of £755.22, an amount calculated by the health board finance department. A breakdown of this is shown in Table 3.


    It was assumed a patient is transferred from the emergency department (ED) to a ward after 4 hours and was likely to remain in hospital for at least a further 48 hours at a cost of £755.22
    ED:
  • Nurse care and housekeeper/environment
  • Doctor assessment at FP2 rate
  • ED triage
  • First hour cost made up of the above four plus blood tests
  • Each subsequent hour in ED
  • ED discharge
  • £495.22
    One-day hospital stay £130.00

    The secondary transfer cost to return the patient home or to another preferred place of care, via the non-emergency patient transport service adds a further £56.42; this figure was supplied by the WAST finance department.

    The respond and admit to the ED data in Table 2 is based on a cost of £1084.06(for ambulance response to 999 call, discharge from ED after 4 hours, 48-hour hospital stay plus ambulance discharge to patient's preferred place of care.

    The introduction of JIC medication in WAST resulted in an annual cost avoidance of £30 121.28 during the 12-month review period, with an average saving of £381.28 per patient (Figure 4).

    Figure 4. Cost comparison of Welsh ambulance service paramedic administering just-in-case medication and keeping the patient in their preferred place of care versus admission to hospital by ambulance

    Discussion

    Although the primary trigger for introducing JIC medications onto ambulances in Wales was to support patients with severe COVID-19 infection in the community, results highlight that symptoms associated with end-stage cancer are the most common condition palliated. End-stage patients with frailty and/or dementia were the second highest group requiring symptom management from the JIC medicines, with those with severe COVID-19 infection being the third highest group.

    It was widely reported during the COVID-19 pandemic that many cancer patients were being diagnosed at a later stage in their disease than would have happened before the pandemic, largely owing to cancer screening being suspended or delayed and routine diagnostic work being deferred (Maringe et al, 2020). It is possible that this impacted on the need for cancer patients to access 999 for symptom management.

    The most common symptom requiring use of JIC medication by a paramedic was breathlessness. Morphine was the most frequently administered medication.

    In circumstances necessitating urgent symptom control where ambulance or a patient's own JIC medications were administered, 67% and 69% respectively of such patients were in the last 48 hours of life, highlighting the crucial role paramedics have in supporting patients at a critical time, and that unscheduled care 999 calls are not uncommon as patients near death.

    Figures on the relative frequency of ambulance versus patient's own JIC medications being administered during the review period indicates morphine and midazolam were the most commonly administered medications (Figure 3). This information, in combination with Figure 2 and acknowledging that 67% of patients died within 48 hours of accessing 999, would indicate that symptoms of pain, breathlessness and agitation in the last days of life are not uncommon, and should therefore be anticipated when supporting or discharging EoLC patients into the community.

    A full health economic evaluation including costs, outcomes and downstream effects of the introduction of JIC medicines in ambulances will need to be undertaken in the future to evaluate all costs and benefits of the new service.

    The data captured, in terms of adverse events and health economics, supports JIC medications remaining available on ambulances as a symptom control option after the pandemic. Outcomes of JIC medicine administration indicate it to be effective as no patient who received JIC medicine was transferred to hospital.

    Bowers et al (2019) state that ‘GPs and community nurses frequently recall situations where drugs were not issued in a timely manner’, resulting in the medicines not being available when needed. The introduction of JIC medications onto ambulances reduces inequity of access to these vital medicines for patients.

    A process change regarding verbal orders is required as the verbal order process is said to be acceptable only in exceptional circumstances. As the NHS moves out of COVID-19 pandemic measures and moves to a recovery phase, patient group directives will be developed, allowing paramedics to administer these medications in emergency situations without need for a verbal order. Shared decision-making with a doctor will still be encouraged before administration.

    Key Points

  • For many end-of-life patients in the community who require pharmacological symptom management in the last days of life, just-in-case medicines will not have been pre-emptively prescribed
  • Over a 12-month period, 67% of patients requiring Welsh Ambulance Services NHS Trust just-in-case medications for urgent symptom control were in their last 48 hours of life, highlighting the crucial role paramedics play in community end-of-life care
  • Symptoms of pain, breathlessness and agitation in the last days of life are not uncommon and should be anticipated and planned for in end-of-life care patients in the community
  • Paramedic use of just-in-case medications to manage symptoms in the last days of life prevents avoidable hospital admissions
  • CPD Reflection Questions

  • How confident are you in your knowledge about the commonly prescribed just-in-case medications and when you as a paramedic should consider administering them?
  • Are you recognising the common symptoms associated with end of life and therefore when just-in-case medication administration may be appropriate?
  • Are you recognising and associating end-stage frailty as an end-of-life condition?