References
Is IV paracetamol as effective an analgesic as IV morphine for patients in non-cardiac pain? A literature review
Abstract
Since the introduction of IV paracetamol to UK ambulance services in 2012 there has been some debate as to which is the better analgesic, IV paracetamol or IV morphine. This literature review was designed to compare the effectiveness of IV paracetamol and IV morphine and consider whether IV paracetamol has any morphine sparing effects. A clinical question was constructed asking: ‘Is IV paracetamol as effective an analgesic as IV morphine for patients in non-cardiac pain?’ and inputted into a variety of journal databases. This returned 2 952 articles, of which 60 abstracts were read and 9 were reviewed, after relevant exclusions were made. It was found that IV paracetamol is as effective as IV morphine and consistently causes fewer adverse reactions, if given as a stand-alone medication. The review suggests that IV paracetamol could significantly reduce the dose of IV morphine required for post-operative patients. The review recommends that paramedics should favour administering IV paracetamol rather than IV morphine, if the clinician is faced with a choice. Current guidelines need to be updated in line with current research that demonstrates the effectiveness and safety of IV paracetamol.
In 2012, intravenous (IV) paracetamol was introduced to the range of analgesics available to paramedics. The Association of Ambulance Chief Executives (AACE) stated that IV paracetamol is effective at reducing opioid requirements and can be used for patients in severe pain as part of a balanced pain regime (AACE, 2013: 337). The AACE also state that IV paracetamol should be considered in the presence of musculoskeletal pain or when morphine is contraindicated (AACE, 2013: 8). IV paracetamol also has a greater safety profile, with side effects such as hypotension being extremely rare, whereas morphine has a far greater range of side effects including respiratory depression, nausea and vomiting (AACE, 2013). These side effects could cause detriment to the patient experience and must be taken into account when deciding on a pain regime. Therefore, adverse reactions and their incidences of occurrence have been included within this review.
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